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In this episode we return to turning the open educational nursing resource for nursing pharmacology into audio, we'll start with the 1st edition antimicrobials then move on to the new second edition with the next topic.

Chapter 3.6 of the Nursing Pharmacology guide focuses on cephalosporins, a class of antibiotics similar to penicillins. The chapter covers their mechanism (cell wall disruption), indications (skin, bone, respiratory infections), different generations with expanding spectra, and administration considerations. It also highlights monitoring for allergies, renal impairment, and possible disulfiram-like reactions with alcohol. Patient education emphasizes avoiding alcohol and reporting signs of superinfection.

1. Cephalosporins work primarily by:
   a) Inhibiting protein synthesis
   b) Disrupting cell wall synthesis
   c) Altering DNA replication
   d) Blocking RNA transcription
2. Which generation of cephalosporins is effective against MRSA?
   a) 1st generation
   b) 2nd generation
   c) 4th generation
   d) 5th generation
3. What side effect may occur when consuming alcohol with cephalosporins?
   a) Increased appetite
   b) Hair loss
   c) Disulfiram-like reaction
   d) Drowsiness
4. Patients with allergies to penicillin might also react to:
   a) Cephalosporins
   b) Tetracyclines
   c) Aminoglycosides
   d) Fluoroquinolones
5. What should be monitored when administering cephalosporins to a patient with renal impairment?
   a) Blood pressure
   b) Liver enzymes
   c) Blood urea nitrogen (BUN) and creatinine
   d) Heart rate

1. b) Disrupting cell wall synthesis
2. d) 5th generation
3. c) Disulfiram-like reaction
4. a) Cephalosporins
5. c) Blood urea nitrogen (BUN) and creatinine

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