Matt Maiocco and Jennifer Lee Chan discuss the 49ers' mounting injuries entering their prime-time matchup with the Bills on NBC's "Sunday Night Football," including a previously undisclosed ankle fracture to star linebacker Fred Warner. Matt and Jennifer also analyze which three players on offense and defense have performed significantly worse compared to their standout 2023 seasons. Later, Matt and Greg Papa discuss if inclement weather will play a role in Buffalo, as well as keys to San Francisco making the Week 13 matchup competitive.

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(1:00) 49ers injury updates

(10:00) Comparing 2023 49ers to 2024 team, which mathematically is still in the playoff hunt

(13:00) Offensive, defensive players whose production fell significantly between last season and this season

(22 :00) How inclement weather in Buffalo could affect SNF game

(24:00) Which backup QB should play if Purdy sits out again?

(32:00) Keys to 49ers coming out competitive vs. Bills

Matt Maiocco and Jennifer Lee Chan discuss how the 49ers struggled mightily in Week 12 against the Green Bay Packers. From miscues to mishaps and many missed tackles, Matt and Jennifer breakdown how the 49ers were out-performed on all three phases. Later, Matt and Jennifer assess if the 49ers can build any momentum down the final stretch of the season.

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(1:00) 49ers "embarrassed" by Packers, got "bullied"

(5:15) CMC's struggles continue in third game since returning

(15:15) Special teams again make ‘back-breaking’ miscues

(22:00) Can the 49ers' end with some semblance of momentum to end the season

(30:30) At lot of the 49ers' offseason plans, potential changes ride on the final six games

Kyle Shanahan sits down with Greg Papa to preview the 49ers' Week 12 matchup against the Packers. Kyle reflects on his previous games against Matt LaFleur, the challenges of slowing down Jordan Love, and the importance of Sunday’s game to the 49ers’ playoff chances.

Matt Maiocco and Jennifer Lee Chan analyze the news that Brock Purdy and Nick Bosa will be out for the 49ers’ crucial game against the Green Bay Packers on Sunday. Matt and Jennifer break down what to expect from Brandon Allen at QB1 and which 49ers will need to step up for San Francisco to have a chance to win at Lambeau Field.

Matt Maiocco and Jennifer Lee Chan examine how the 49ers' playoff hopes hang in the balance as they travel to Lambeau Field for a Week 12 game against the Packers. They also assess the growing 49ers injury list and who likely will suit up in Green Bay. Later, Matt and Greg Papa circle back to the narrow playoff path the 49ers must navigate with seven games left in the regular season.

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(6:15) Margin for error is slim, but Kyle Shanahan hasn't lost the locker room

(13:30) 49ers injury updates

(38:00) Playoff implications of a win or a loss in Green Bay

(43:00) Playoff permutations reviewed with Greg Papa

Matt Maiocco and Jennifer Lee Chan discuss how inconsistencies plagued the 49ers' offense as they fell in stunning fashion to the Seattle Seahawks in Week 11. Matt and Jennifer also assess San Francisco's playoff chances ahead of a tough stretch in the schedule. Later, Matt sits down with fourth-year defensive back Deommodore Lenoir on the heels of his five-year contract extension to discuss his unexpected draft night, how the 49ers are a perfect fit and what we can expect from the self-proclaimed "hyena" for years to come.

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1:00 – 49ers are epitome of ‘average’ team this season

8:00 - ‘Infuriating’ loss – Never seen captains CMC, Bosa, Warner so down after loss

16:00 Great team on paper, but roster talent and stats haven't translated to wins

25:00 Super Bowl hangover real, 49ers losing high-level postseason games - mental/physical fatigue kicking in? Lacking killer-instinct

33:30 Positives can be drawn from young, developing secondary, really showing signs you can build team around

Kyle Shanahan sits down with Greg Papa to preview the 49ers' Week 11 matchup against the Seahawks. Kyle breaks down Christian McCaffrey's impact, Jauan Jennings' role, and why slowing down Kenneth Walker III will be key to San Francisco's success on Sunday.

Matt Maiocco and Jennifer Lee Chan discuss Deommodore Lenior's five-year contract extension with the 49ers and how he can help stabilize their secondary unit for years to come. They also assess how Christian McCaffrey is settling back into his starting role with NFC West rival Seattle looming on the horizon, Later, Matt and Greg Papa revisit the Lenoir contract, dissect his rapid development since joining the organization and explain why he might be the most important piece on the 49ers’ defense this season.

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(5:00) 49ers’ rest disadvantage very apparent this season

(12:30) 49ers being proactive instead of reactive with Lenoir deal

(23:40) CMC usage was higher than initially thought, but he came out of it healthy

(40:00) Lenior's rapid development, how he’s having an All-Pro worthy season