Emmy-nominated actress Yvonne Strahovski first turned heads as a CIA agent in the popular NBC series Chuck, followed by a role in another hit show, Dexter, and, of course, as Serena Joy Waterford in the award-winning series The Handmaid's Tale.

Yvonne joins Sophia to chat about the final season of The Handmaid's Tale, including how she feels about the show coming to an end, the scenes that made her feel uncomfortable, how significant and relevant the show is in the current political space, and how she would love to dive into a comedy next!

Plus, she talks about juggling her globe-trotting career with motherhood, what she was like as a child, and starring and executive-producing her new horror series, Teacup, on Peacock!

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It's Quinn's gallery opening and Rob is concerned about Clay's behavior, interpreting it as if he’s treating Katie like a mistress. Joy reveals she had to fight to play Haley low energy and how clearly she remembers filming the scenes where Haley is overwhelmed with grief. They discuss what they loved about the dramatic scene where Skills punches Mouth. And, Joy reflects on their late colleague Paul Teal, who portrayed the character Josh.

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Rob & Joy talk about what it was like filming during Halloween in Wilmington and imagine how their TV characters would have celebrated Friendsgiving. They reminisce over their favorite directors and what they loved about them while predicting who would've survived The Walking Dead.

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Zachary Quinto has thrilled audiences with his performances on stage, film, and TV, starring in huge hits like Heroes and American Horror Story and playing the iconic character Spock in the Star Trek reboot. The brilliant actor is now tackling a new role in NBC's medical drama "Brilliant Minds."

In a candid chat, pals Zachary and Sophia get very vulnerable about the election's outcome and how they plan to move forward. Zachary also talks about his journey through sobriety, shares the impact meditation has had on him, the biggest shift in his life that set him on the path to acting, and how booking Heroes and Star Trek at age thirty affected him.

Plus, Zachary reveals why he initially was not interested in playing the leading man in NBC's new medical drama, "Brilliant Minds," and what changed his mind.

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The James sisters are reunited and it feels SO good!

Joy welcomes her on screen sisters Shantel VanSanten & Lindsey McKeon to
discuss how differently they each grieved their TV mom’s passing. Shantel shares how her real life had an emotional parallel to this episode. Rob has a hot take on Clay's new stalker. And if you ever had a question about who was the favorite James sister, the Queens give you their vote!

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Comedian, performer, and host Amber Ruffin knew she was funny at a young age, so it's no surprise she is making viewers laugh out loud on "Late Night with Seth Meyers" and CNN's "Have I Got News For You."

Amber joins Sophia to talk about her road to comedy, making history as the first black woman ever to write for a late-night talk show in America, her decision to share her own experiences with police brutality on late night, writing a best-selling book with her sister, her decision to come out as queer earlier this year, and why humor is such an important force for good.

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The Queens are all back together and they're praising Joy for her directorial work this episode. She reminisces on being behind the camera of this episode and how she chose to navigate the heavy emotions of it.

Rob, Joy and Sophia discuss the surprising chemistry between Mouth and Miss Lauren, the comic relief between Victoria and Sophia, and the James/Scott family's emotional journey to accepting Lydia's illness.

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From a superstar athlete to an Emmy winner, Sophia, Joy, and Rob are sharing their favorite guest stars from OTH. They envision what a Tree Hill summer camp would look like and which counselors they each would be.

Plus, they each pick their favorite moment from filming they will talk about for generations to come.

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