Peter Parker is caught in a complicated web. Working in a cutting-edge laboratory, he's a young scientist who's trying to make a difference. Yet he's constantly burdened by the responsibilities of his second career as the crime-fighting Spider-Man. Wilson Fisk - the so-called Kingpin of Crime - has returned to New York, establishing himself publicly as an altruistic entrepreneur and philanthropist. Spider-Man knows better, but he can't uncover Fisk's scheme, which, if executed, will make the crime lord too big to fail. 

Beginning with a novella by Spider-Man's co-creator Stan Lee and veteran Marvel writer Peter David retelling the wall-crawler's origin, this exciting anthology has original stories featuring one of the world's most enduring heroes.

Born to a rarified breed of Russian aristocracy, Kraven the Hunter had stalked and killed every animal known to man and considered himself the world's best big-game hunter. It was this confidence that brought him to New York years ago, in an obsessive quest to hunt what he considered the city's greatest prey: Spider-Man. But his target eluded him time and again, mocking him at every turn.   

This exciting new anthology has over a dozen original tales starring the vicious foes of Marvel's superheroes: Greg Cox's chronicle of the Super-Skrull's conflict with the Avengers, Michael Jan Friendman's story of evil Loki's latest attempt to snare his stepbrother Thor, Adam-Troy Castro's tale of a mutant who brings Magneto and X-Men's Professor X together in a unique manner, Glenn Greenberg's pairing of Venom and the Absorbing Man in an unlikely jailbreak. 

On several occasions, a half-dozen of Spider-Man's greatest enemies have banded together as the Sinister Six. Now, at the behest of a deadly benefactor known only as the Gentleman, the Chameleon has been tasked with assembling a new Sinister Six with the most ambitious scheme yet! Soon, he has recruited the Vulture, freed Electro and Dr. Octopus from prison, and been joined by the Gentleman's mysterious ward, Pity. That only leaves Mysterio, but the master of illusion has a plan of his own. 

A brand-new designer drug arrives in New York City with the force of a hurricane: Triple X, a potentially lethal combination of ecstasy and gamma radiation that is literally turning users from the shadowy, dank alleys to the glittering, raucous party circuit into living, rampaging nightmares. For high school science teacher Peter Parker, Triple X's onslaught on some of his students and his wife's professional life is as dangerous as it is unexpected.  

Brian Timilty is running for mayor on an anti-superhero ticket, and the amazing Spider-Man is his biggest target. But Timilty is secretly the pawn of Tyler Stewart, a wealthy businessman seeking to take over New York's mobs. To ensure his success, Stewart hires two of Spider-Man's deadliest foes, Electro and the Rhino, and executes a plan guaranteed to keep the wall-crawler from interfering with his grand designs: He frames Spider-Man for a grisly murder! Forced into hiding, Spider-Man must find a way to clear his name without being shot on sight, for he is wanted dead or alive.

Stark Enterprises has unleashed the Infinite Engine, which promises to be an energy source unlike anything ever seen before. But saboteurs from both A.I.M. and Hydra have set their sights on the engine as well - along with Dr. Doom. When a respected scientist is killed and the Engine taken over, Spiderman and Iron Man join forces to safeguard the Infinite Engine - and all of humanity. 

It begins with the murder of a New York socialite. Following the trail of the killers, Spider-Man is soon confronted by one of his oldest, deadliest enemies: the Lizard. Once a respected scientist, Dr. Curt Connors created a serum that he hoped would regenerate the arm he had lost years before. But the serum did more than regrow his arm - it turned him into the savage, human-hating creature called the Lizard. 

The Lizard is wreaking havoc throughout the Everglades, as he seeks a cure for his dual identity as the reptilian villain and the human scientist Dr. Curt Connors - the result of an experiment gone horribly wrong. Spidey's attempts to halt the Lizard's rampage lead him to a web of intrigue and danger that may spell the destruction of a space-shuttle launch. The action heats up as Venom, the alien symbiote who wants Spider-Man dead, arrives, targets the Lizard for death, and won't let anyone stand in his way!

Miles Morales has a lot going on, what with moving to a new neighborhood, dealing with the loss of his father, and the whole gaining superpowers thing. After a misunderstanding with the law, Miles questions what it means to be a hero when people are ready to believe the worst of you. Tempted by the power and freedom of his new abilities, Miles must decide what kind of Spider-Man he wants to be. When Vulture starts wreaking havoc across the city with his new accomplice Starling, Miles can't just sit back and watch. 

Hoping to snag some rent-paying photos of his arachnid-like alter ego in action, Peter Parker goes looking for trouble - and finds it in the form of a mysterious, mythical stone tablet coveted by both the Kingpin and the Maggia. Caught in the crosshairs of New York's most nefarious villains, Peter also runs afoul of his friends - and the police! His girlfriend, Gwen Stacy, isn't too happy with him either. And the past comes back to haunt him when the Maggia's assumed-dead leader resurfaces in pursuit of the troublesome tablet.

MODOK, the Mental Organism Designed Only for Killing, is the product of the corrupt scientists of A.I.M (Advanced Idea Mechanics). Iron Man learns that MODOK has turned his back on his creators, destroying an A.I.M. undersea lab, leaving only one devastated survivor. But MODOK's fearsome plan involves more than taking revenge... Now Iron Man must recruit his fellow heroes War Machine, Captain America, and the Black Panther to help him stop MODOK from gathering the materials he needs to create the ultimate weapon - a weapon that could spell humanity's doom!  

In a Manhattan warehouse, an innocent man has been murdered during a mysterious crime. Evidence points to the involvement of Venom - the alien symbiote obsessed with Spider-Man's destruction. Yet Venom has always safeguarded innocent lives. Has Venom gone completely around the bend, or is there another suspect? Spider-Man thinks there is more to the crime than meets the eye. The specter of the Hobgoblin, one of Spider-Man's nastiest foes, falls on a series of thefts and leads the web-slinger to a deadly secret that may cause New York's destruction. 

J. Jonah Jameson, the publisher of the Daily Bugle, has denounced Spider-Man from the beginning, convincing New Yorkers to see him as a criminal and a menace. But when a robot attack on Manhattan injures Peter Parker's students and Jameson blames Spider-Man, their feud takes on a personal dimension.